In clinical trials, patient engagement is a critical factor that influences recruitment, retention, and overall success. However, generic, one‑size‑fits‑all approaches often fail to meet the diverse needs of participants. This talk explores how AI‑powered personalization is transforming the way we engage with patients, making clinical trials more accessible, relatable, and effective. We will delve into real-world applications of AI‑driven tools like the Pediatric Engagement Platform (PEP) and Non‑Pediatric Engagement Platform (NPEP), which leverage personalized videos, animations, and multilingual content to simplify complex medical concepts and empower patients. By using AI to create tailored experiences, trials can reduce dropout rates, improve adherence, and foster greater trust among participants.This session will also discuss the ethical implications and the importance of integrating culturally competent materials and patient input when deploying these technologies. Attendees will leave with actionable insights on leveraging AI to revolutionize patient‑centric clinical research. (Learn more here: https://www.linkedin.com/posts/ina-burgstaller-5198a114_clinicaltrials-patientengagement-pep-activity-7287157737136766977-oRRC?utm_source=share&utm_medium=member_desktop)