Others titles
- Clinical Trial on Stroke
- RCT on Stroke
Keywords
- Stroke
- Clinical trials
- RCTs
- Randomized Controlled Trials
- Acute Stroke
- Ischaemic Stroke
- Haemorrhagic Stroke
- Pulmonary embolism
- Coronary heart disease
- Pneumonia
International Stroke Trial Database
The International Stroke Trial (IST) dataset includes data on 19,435 patients and 112 variables. For each randomized patient, data were extracted on the variables assessed at randomization, at the early outcome point, and at 6-months. This dataset provides a source of primary data and is available for public use for the conduct of secondary analyses and in the planning of future trials particularly in older patients and in resource-poor settings given the age distribution of the dataset.
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Description
The International Stroke Trial (IST) is one of the largest randomized trials ever conducted on individual patients in acute stroke. The IST dataset includes data on 19 435 patients with acute stroke, with 99% complete follow-up. Over 26.4% patients were aged over 80 years at study entry. Background stroke care was limited and none of the patients received thrombolytic therapy.
This clinical trial was conducted between 1991 and 1996 and a pilot phase between 1991 to and 1993. This study is a large, prospective, randomized controlled trial, with 100% complete baseline data and over 99% complete follow-up data. For each randomized patient, data were extracted on the variables assessed at randomization; the early outcome point was 14-days after randomization or prior discharge, and at 6-months and provided as an analyzable database. The aim of the trial was to establish whether early administration of aspirin, heparin, both or neither influenced the clinical course of an acute ischaemic stroke.
The dataset mentioned plays a crucial role in supporting applications of Generative AI in healthcare by enhancing terminology accuracy and facilitating better communication among medical professionals and patients.
About this Dataset
Data Info
Date Created | 2011-11-02 |
---|---|
Last Modified | 2011-11-02 |
Version | 2 |
Update Frequency |
Never |
Temporal Coverage |
1991 to 1996 |
Spatial Coverage |
World |
Source | John Snow Labs; Department of Biostatistics, Vanderbilt University; University of Edinburgh, Department of Clinical Neurosciences; |
Source License URL |
No data |
Source License Requirements |
N/A |
Source Citation |
N/A |
Keywords | Stroke, Clinical trials, RCTs, Randomized Controlled Trials, Acute Stroke, Ischaemic Stroke, Haemorrhagic Stroke, Pulmonary embolism, Coronary heart disease, Pneumonia |
Other Titles | Clinical Trial on Stroke, RCT on Stroke |
Data Fields
Name | Description | Type | Constraints |
---|---|---|---|
Hospital_Number | Hospital number | integer | level : Nominalrequired : 1 |
Delay_in_Hours_at_Randomization | Delay between stroke and randomization in hours | integer | level : Ratio |
Conscious_State_at_Randomization | Conscious state at randomization where F - fully alert, D - drowsy, U - unconscious | string | - |
Gender | Sex where Value: Male, Female | string | - |
Age_in_Years | Age in years of subjects | integer | level : Ratio |
Is_Symptoms_Noted_on_Waking | Symptoms noted on waking where | boolean | - |
Is_Atrial_Fibrillation_Coded | Atrial fibrillation; not coded for pilot phase - 984 patients | boolean | - |
Is_CT_Before_Randomization | CT before randomization | boolean | - |
Is_Infarct_Visible_on_CT | Infarct visible on CT | boolean | - |
Is_Heparin_Before_Randomization | Heparin within 24 hours prior to randomization | boolean | - |
Is_Aspirin_Before_Randomization | Aspirin within 3 days prior to randomization | boolean | - |
Systolic_Blood_Pressure_at_Randomization | Systolic blood pressure at randomisation (mmHg) | integer | level : Ratio |
Face_Deficit | Presence or absence of face deficit where Y = True, N = False, C=can't assess | string | - |
Arm_Hand_Deficit | Presence or absence of an arm or hand deficit where Y = True, N = False, C=can't assess | string | - |
Leg_Foot_Deficit | Presence or absence of leg or foot deficit where Y = True, N = False, C=can't assess | string | - |
Dysphasia | Presence or absence of dysphasia where Y = True, N = False, C=can't assess | string | - |
Hemianopia | Presence or absence of hemianopia where Y = True, N = False, C=can't assess | string | - |
Visuospatial_Disorder | Presence or absence of visuospatial disorder where Y = True, N = False, C=can't assess | string | - |
Cerebellar_Signs | Presence or absence of brainstem or cerebellar signs where Y = True, N = False, C=can't assess | string | - |
Deficit_Others | Presence or absence of other deficit where Y = True, N = False, C=can't assess | string | - |
Stroke_Subtype | A subtype of stroke, either total anterior circulation syndrome (TACS), partial anterior circulation syndrome (PACS), posterior circulation syndrome (POCS) and lacunar syndrome (LACS), and other (OTH) | string | - |
Date_of_Randomization_Oxford | Year and month of randomization done every March 1 from 1991 to 1996; the date is in Oxford format (yyyy-mm); date of randomization per country is coded by country and year (code-yy) | string | - |
Local_Time_in_Hours | Local time in hours; (99-missing data) of randomization dropped | integer | level : Ordinal |
Local_Time_in_Minutes | Local time in minutes; (99-missing data) of randomisation | integer | level : Ordinal |
Local_Day_of_Week | Estimate of the local day of the week (assuming date is Oxford) where 1 - Sunday, 2-Monday, 3-Tuesday, 4-Wednesday, 5-Thursday, 6-Friday, | string | - |
Is_Trial_Aspirin_Allocated | Trial aspirin allocated | boolean | - |
Trial_Heparin_Allocated | Trial heparin allocated (M/L/N) where M in the main trial is coded as H=high in pilot; where M = high in the main trial, H = high in pilot, L = low in the main trial and N = avoid heparin; The terminology for the allocated dose of unfractioned heparin changed slightly from the pilot to the main study. Patients were allocated either 12500 units subcutaneously twice daily (coded as H in the pilot and M in the main trial), 5000 units twice daily (coded as L throughout) or to 'avoid heparin' (coded as N throughout). | string | - |
Aspirin_Given_For_14_Days | Aspirin given for 14 days or till death or discharge where Y = True, N = False, U = Unknown | string | - |
Discharged_On_Long_Term_Aspirin | Discharged on long term aspirin (Y/N) where Y = True, N = False, U = Unknown | string | - |
Low_Dose_Heparin_Given_For_14_Days | Low dose heparin given for 14 days or till death/discharge where Y = True, N = False, U = Unknown | string | - |
Medium_Dose_Heparin_Given_For_14_Days | Medium dose heparin given for 14 days or till death/discharge where Y = True, N = False, U = Unknown | string | - |
Is_Medium_Dose_Heparin_Given_For_14_Days_in_Pilot | Medium dose heparin is given for 14 days etc in the pilot (combine with above) | boolean | - |
Time_In_Days_On_Trial_Treatment | Estimate of time in days on trial treatment | integer | level : Ordinal |
Non_Trial_Subcutaneous_Heparin | Non trial subcutaneous heparin (Y/N) where Y = True, N = False, U = Unknown | string | - |
Non_Trial_Intravenous_Heparin | Non trial intravenous heparin where Y = True, N = False, U = Unknown | string | - |
Non_Trial_Antiplatelet_Drug | Non trial antiplatelet drug where Y = True, N = False, U = Unknown | string | - |
Anticoagulants_Others | Other anticoagulants given where Y = True, N = False, U = Unknown | string | - |
Glycerol_or_Manitol | Glycerol or manitol given where Y = True, N = False, U = Unknown | string | - |
Steroids | Steroids given where Y = True, N = False, U = Unknown | string | - |
Calcium_Antagonists | Calcium antagonists given where Y = True, N = False, U = Unknown | string | - |
Haemodilution | Occurence of haemodilution where Y = True, N = False, U = Unknown | string | - |
Carotid_Surgery | Occurence of carotid surgery where Y = True, N = False, U = Unknown | string | - |
Thrombolysis | Occurence of thrombolysis where Y = True, N = False, U = Unknown | string | - |
Major_Non_Cerebral_Haemorrhage | Occurence of major non-cerebral haemorrhage where Y = True, N = False, U = Unknown | string | - |
Days_Elapsed_From_Randomization_to_Major_Non_Cerebral_Haemorrhage | Number of days elapsed from randomization to occurrence of major non-cerebral hemorrhage | integer | level : Ratio |
Comment_on_Major_Non_Cerebral_Haemorrhage | Comment on the occurrence of major non-cerebral hemorrhage | string | - |
Side_Effect_Others | Occurrence of other side effect where Y = True, N = False, U = Unknown | string | - |
Days_Elapsed_From_Randomization_to_Side_Effects | Number of days elapsed from randomization to occurrence of other side effects | integer | level : Ratio |
Comment_on_Side_Effect | Comment on the occurrence of other side effects | string | - |
Ischaemic_Stroke | Ischaemic stroke as final diagnosis of initial event where Y = True, N = False, U = Unknown | string | - |
Haemorrhagic_Stroke | Hemorrhagic stroke as a final diagnosis of initial event where Y = True, N = False, U = Unknown | string | - |
Indeterminate_Stroke | Indeterminate stroke as final diagnosis of initial event where Y = True, N = False, U = Unknown | string | - |
Not_A_Stroke | Not a stroke as final diagnosis of initial event where Y = True, N = False, U = Unknown | string | - |
Comment_on_Final_Diagnosis_of_Initial_Event | Comment on final diagnosis of the initial event | string | - |
Recurrent_Ischaemic_Stroke | Occurrence of ischaemic recurrent stroke within 14 days where Y = True, N = False, U = Unknown | string | - |
Days_Elapsed_From_Randomization_to_Recurrent_Ischaemic_Stroke | Number of days elapsed from randomization to occurrence of recurrent ischaemic stroke | integer | level : Ratio |
Recurrent_Haemorrhagic_Stroke | Occurrence of haemorrhagic stroke within 14 days where Y = True, N = False, U = Unknown | string | - |
Days_Elapsed_From_Randomization_to_Recurrent_Haemorrhagic_Stroke | Number of days elapsed from randomization to occurrence of hemorrhagic stroke | integer | level : Ratio |
Unknown_Type | Occurrence of unknown type stroke within 14 days where Y = True, N = False, U = Unknown | string | - |
Days_Elapsed_From_Randomization_to_Unknown_Type | Number of days elapsed from randomization to occurrence of an unknown type of stroke | integer | level : Ratio |
Pulmonary_Embolism_Within_14_Days | Occurrence of pulmonary embolism within 14 days where Y = True, N = False, U = Unknown | string | - |
Days_Elapsed_From_Randomization_to_Pulmonary_Embolism | Number of days elapsed from randomization to occurrence of pulmonary embolism within 14 days | integer | level : Ratio |
Discharged_Alive_From_Hospital_Within_14_Days | Discharged alive from hospital within 14 days where Y = True, N = False, U = Unknown | string | - |
Days_Elapsed_From_Randomization_to_Discharged_Alive_From_Hospital | Number of days elapsed from randomization to discharge alive from the hospital within 14 days | integer | level : Ratio |
Discharge_Destination | Discharge destination where A = Home, B = Relatives home, C = Residential care, D = Nursing home, E = Other hospital departments and U-Unknown | string | - |
Dead_on_Discharge_Within_14_Days | The occurrence of death upon discharge where Y = True, N = False, U = Unknown; This death is not necessarily within 14 days of randomization | string | - |
Days_Elapsed_From_Randomization_to_Dead_on_Discharge | Number of days elapsed from randomization to dead on discharge where death is not necessarily within 14 days of randomization | integer | level : Ratio |
Cause_of_Death_Within_14_Days | Cause of death where 1 = Initial stroke, 2 = Recurrent stroke (ischaemic or unknown), 3 = Recurrent stroke (haemorrhagic, 4= Pneumonia, 5 = Coronary heart disease, 6 = Pulmonary embolism, 7 = Other vascular or unknown, 8 = Non-vascular and 0 = unknown | string | - |
Comment_on_Death_Within_14_Days | Comment on death within 14 days | string | - |
Dead_at_Six_Month_Follow_Up | Occurrence of death at six month follow-up where Y = True, N = False, U = Unknown | string | - |
Days_Elapsed_From_Randomization_to_Date_of_Last_Contact | Number of days elapsed from randomization to date of the last contact | integer | level : Ratio |
Days_Elapsed_From_Randomization_to_Death_at_Six_Month_Follow_Up | Number of days elapsed from randomization to death at six-month follow-up where death is not necessarily within 6 months of randomization | integer | level : Ratio |
Cause_of_Death_at_Six_Month_Follow_Up | Cause of death where 1 = Initial stroke, 2 = Recurrent stroke (ischaemic or unknown), 3 = Recurrent stroke (haemorrhagic, 4= Pneumonia, 5 = Coronary heart disease, 6 = Pulmonary embolism, 7 = Other vascular or unknown, 8 = Non-vascular and 0 = unknown | string | - |
Comment_on_Death_at_Six_Month_Follow_Up | Comment on death at six-month follow-up | string | - |
Fully_Recovered_at_Six_Month_Follow_Up | Fully recovered at six month follow-up where Y = True, N = False, U = Unknown | string | - |
Dependent_at_Six_Month_Follow_Up | Dependent at six month follow-up where Y = True, N = False, U = Unknown | string | - |
Place_of_Residence_at_Six_Month_Follow_Up | Place of residence at six month follow-up where A = Home, B = Relatives home, C = Residential care, D = Nursing home, E = Other hospital departments and U = Unknown | string | - |
On_Antiplatelet_Drugs_at_Six_Month_Follow_Up | On antiplatelet drugs at six month follow-up where Y = True, N = False, U = Unknown | string | - |
On_Anticoagulants_at_Six_Month_Follow_Up | On anticoagulant at six month follow-up where Y = True, N = False, U = Unknown | string | - |
Days_Elapsed_From_Randomization_to_Date_Discharge_Form_Received | Number of days elapsed from randomization to date discharged form received | integer | level : Ratio |
Days_Elapsed_From_Randomization_to_Date_at_Six_Month_Follow_Up_Done | Number of days elapsed from randomization to date at six-month follow-up | integer | level : Ratio |
Abbreviated_Country_Code | Abbreviated country code | string | - |
Country_Code | Country code | integer | level : Nominal |
Days_Elapsed_From_Randomization_to_Date_Discharge_Form_Completed | Number of days elapsed from randomization to date discharge form completed | integer | level : Ratio |
Coding_of_Compliance | Coding of compliance where provisional categories for non-compliance are the following: | string | - |
Is_Compliant_for_Aspirin | Compliance with aspirin | boolean | - |
Is_Compliant_for_Heparin | Compliance with heparin | boolean | - |
Is_Death_Indicator | Indicator for death | boolean | - |
Time_of_Death_in_Days | Time of death or censoring in days | integer | level : Ordinal |
Predicted_Probability_of_Death | Predicted probability of death or dependence at 6 month | number | level : Ratio |
Predicted_Probability_of_Death_at_Six_Month | Predicted probability of death at 6 month | number | level : Ratio |
Predicted_Probability_of_Death_at_14_Days | Predicted probability of death at 14 days | number | level : Ratio |
Is_Dead_or_Alive_at_14_Days | Known to be dead or alive at 14 days where 1 = yes and 0 = no; this does not necessarily mean that we know the outcome at 6 months | boolean | - |
Is_Death_Indicator_at_14_Days | The indicator of death at 14 days | boolean | - |
Six_Month_Outcome | Six month outcome where 1 = dead, 2 = dependent, 3 = not recovered, 4 = recovered, 0 or 9 = missing status | string | - |
Is_Initial_Stroke_Indicator | Initial stroke as an indicator variable for the specific cause of death | boolean | - |
Is_Recurrent_Ischaemic_or_Unknown_Stroke_Indicator | Recurrent ischaemic or unknown stroke as an indicator variable for the specific cause of death | boolean | - |
Is_Recurrent_Haemorrhagic_Stroke_Indicator | Recurrent hemorrhagic stroke as an indicator variable for the specific cause of death | boolean | - |
Is_Pneumonia_Indicator | Pneumonia as an indicator variable for the specific cause of death | boolean | - |
Is_Coronary_Heart_Disease_Indicator | Coronary heart disease as an indicator variable for the specific cause of death | boolean | - |
Is_Pulmonary_Embolism_Indicator | Pulmonary embolism as an indicator variable for the specific cause of death | boolean | - |
Is_Other_Vascular_Indicator | Other vascular or unknown as an indicator variable for the specific cause of death | boolean | - |
Is_Non_Vascular_Indicator | Non-vascular as an indicator variable for the specific cause of death | boolean | - |
Is_Haemorrhagic_Stroke_Indicator_Within_14_Days | Cerebral bleed/hemorrhagic stroke within 14 days as an indicator variable for the specific cause of death; this is slightly wider definition than DRSH and is used for analysis of cerebral bleeds | boolean | - |
Is_Ischaemic_Stroke_Indicator_Within_14_Days | The indicator of ischaemic stroke within 14 days | boolean | - |
Is_Indeterminate_Stroke_Indicator_Within_14_Days | The indicator of indeterminate stroke within 14 days | boolean | - |
Is_Any_Stroke_Indicator_Within_14_Days | The indicator of any stroke within 14 days | boolean | - |
Is_Haemorrhagic_Transformation_Indicator_Within_14_Days | The indicator of hemorrhagic transformation within 14 days | boolean | - |
Is_Pulmonary_Embolism_Indicator_Within_14_Days | The indicator of pulmonary embolism within 14 days | boolean | - |
Is_Deep_Vein_Thrombosis_on_Discharge | The indicator of deep vein thrombosis on the discharge form | boolean | - |
Is_Major_Non_Cerebral_Bleed_Indicator_Within_14_Days | The indicator of major non-cerebral bleed within 14 days | boolean | - |
Is_Any_Non_Cerebral_Bleed_Indicator_Within_14_Days | The indicator of any non-cerebral bleed within 14 days | boolean | - |