Others titles

  • Clinical Trial on Stroke
  • RCT on Stroke

Keywords

  • Stroke
  • Clinical trials
  • RCTs
  • Randomized Controlled Trials
  • Acute Stroke
  • Ischaemic Stroke
  • Haemorrhagic Stroke
  • Pulmonary embolism
  • Coronary heart disease
  • Pneumonia

International Stroke Trial Database

The International Stroke Trial (IST) dataset includes data on 19,435 patients and 112 variables. For each randomized patient, data were extracted on the variables assessed at randomization, at the early outcome point, and at 6-months. This dataset provides a source of primary data and is available for public use for the conduct of secondary analyses and in the planning of future trials particularly in older patients and in resource-poor settings given the age distribution of the dataset.

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Description

The International Stroke Trial (IST) is one of the largest randomized trials ever conducted on individual patients in acute stroke. The IST dataset includes data on 19 435 patients with acute stroke, with 99% complete follow-up. Over 26.4% patients were aged over 80 years at study entry. Background stroke care was limited and none of the patients received thrombolytic therapy.

This clinical trial was conducted between 1991 and 1996 and a pilot phase between 1991 to and 1993. This study is a large, prospective, randomized controlled trial, with 100% complete baseline data and over 99% complete follow-up data. For each randomized patient, data were extracted on the variables assessed at randomization; the early outcome point was 14-days after randomization or prior discharge, and at 6-months and provided as an analyzable database. The aim of the trial was to establish whether early administration of aspirin, heparin, both or neither influenced the clinical course of an acute ischaemic stroke.

The dataset mentioned plays a crucial role in supporting applications of Generative AI in healthcare by enhancing terminology accuracy and facilitating better communication among medical professionals and patients.

About this Dataset

Data Info

Date Created

2011-11-02

Last Modified

2011-11-02

Version

2

Update Frequency

Never

Temporal Coverage

1991 to 1996

Spatial Coverage

World

Source

John Snow Labs; Department of Biostatistics, Vanderbilt University; University of Edinburgh, Department of Clinical Neurosciences;

Source License URL

No data

Source License Requirements

N/A

Source Citation

N/A

Keywords

Stroke, Clinical trials, RCTs, Randomized Controlled Trials, Acute Stroke, Ischaemic Stroke, Haemorrhagic Stroke, Pulmonary embolism, Coronary heart disease, Pneumonia

Other Titles

Clinical Trial on Stroke, RCT on Stroke

Data Fields

Name Description Type Constraints
Hospital_NumberHospital numberintegerlevel : Nominalrequired : 1
Delay_in_Hours_at_RandomizationDelay between stroke and randomization in hoursintegerlevel : Ratio
Conscious_State_at_RandomizationConscious state at randomization where F - fully alert, D - drowsy, U - unconsciousstring-
GenderSex where Value: Male, Femalestring-
Age_in_YearsAge in years of subjectsintegerlevel : Ratio
Is_Symptoms_Noted_on_WakingSymptoms noted on waking whereboolean-
Is_Atrial_Fibrillation_CodedAtrial fibrillation; not coded for pilot phase - 984 patientsboolean-
Is_CT_Before_RandomizationCT before randomizationboolean-
Is_Infarct_Visible_on_CTInfarct visible on CTboolean-
Is_Heparin_Before_RandomizationHeparin within 24 hours prior to randomizationboolean-
Is_Aspirin_Before_RandomizationAspirin within 3 days prior to randomizationboolean-
Systolic_Blood_Pressure_at_RandomizationSystolic blood pressure at randomisation (mmHg)integerlevel : Ratio
Face_DeficitPresence or absence of face deficit where Y = True, N = False, C=can't assessstring-
Arm_Hand_DeficitPresence or absence of an arm or hand deficit where Y = True, N = False, C=can't assessstring-
Leg_Foot_DeficitPresence or absence of leg or foot deficit where Y = True, N = False, C=can't assessstring-
DysphasiaPresence or absence of dysphasia where Y = True, N = False, C=can't assessstring-
HemianopiaPresence or absence of hemianopia where Y = True, N = False, C=can't assessstring-
Visuospatial_DisorderPresence or absence of visuospatial disorder where Y = True, N = False, C=can't assessstring-
Cerebellar_SignsPresence or absence of brainstem or cerebellar signs where Y = True, N = False, C=can't assessstring-
Deficit_OthersPresence or absence of other deficit where Y = True, N = False, C=can't assessstring-
Stroke_SubtypeA subtype of stroke, either total anterior circulation syndrome (TACS), partial anterior circulation syndrome (PACS), posterior circulation syndrome (POCS) and lacunar syndrome (LACS), and other (OTH)string-
Date_of_Randomization_OxfordYear and month of randomization done every March 1 from 1991 to 1996; the date is in Oxford format (yyyy-mm); date of randomization per country is coded by country and year (code-yy)string-
Local_Time_in_HoursLocal time in hours; (99-missing data) of randomization droppedintegerlevel : Ordinal
Local_Time_in_MinutesLocal time in minutes; (99-missing data) of randomisationintegerlevel : Ordinal
Local_Day_of_WeekEstimate of the local day of the week (assuming date is Oxford) where 1 - Sunday, 2-Monday, 3-Tuesday, 4-Wednesday, 5-Thursday, 6-Friday,string-
Is_Trial_Aspirin_AllocatedTrial aspirin allocatedboolean-
Trial_Heparin_AllocatedTrial heparin allocated (M/L/N) where M in the main trial is coded as H=high in pilot; where M = high in the main trial, H = high in pilot, L = low in the main trial and N = avoid heparin; The terminology for the allocated dose of unfractioned heparin changed slightly from the pilot to the main study. Patients were allocated either 12500 units subcutaneously twice daily (coded as H in the pilot and M in the main trial), 5000 units twice daily (coded as L throughout) or to 'avoid heparin' (coded as N throughout).string-
Aspirin_Given_For_14_DaysAspirin given for 14 days or till death or discharge where Y = True, N = False, U = Unknownstring-
Discharged_On_Long_Term_AspirinDischarged on long term aspirin (Y/N) where Y = True, N = False, U = Unknownstring-
Low_Dose_Heparin_Given_For_14_DaysLow dose heparin given for 14 days or till death/discharge where Y = True, N = False, U = Unknownstring-
Medium_Dose_Heparin_Given_For_14_DaysMedium dose heparin given for 14 days or till death/discharge where Y = True, N = False, U = Unknownstring-
Is_Medium_Dose_Heparin_Given_For_14_Days_in_PilotMedium dose heparin is given for 14 days etc in the pilot (combine with above)boolean-
Time_In_Days_On_Trial_TreatmentEstimate of time in days on trial treatmentintegerlevel : Ordinal
Non_Trial_Subcutaneous_HeparinNon trial subcutaneous heparin (Y/N) where Y = True, N = False, U = Unknownstring-
Non_Trial_Intravenous_HeparinNon trial intravenous heparin where Y = True, N = False, U = Unknownstring-
Non_Trial_Antiplatelet_DrugNon trial antiplatelet drug where Y = True, N = False, U = Unknownstring-
Anticoagulants_OthersOther anticoagulants given where Y = True, N = False, U = Unknownstring-
Glycerol_or_ManitolGlycerol or manitol given where Y = True, N = False, U = Unknownstring-
SteroidsSteroids given where Y = True, N = False, U = Unknownstring-
Calcium_AntagonistsCalcium antagonists given where Y = True, N = False, U = Unknownstring-
HaemodilutionOccurence of haemodilution where Y = True, N = False, U = Unknownstring-
Carotid_SurgeryOccurence of carotid surgery where Y = True, N = False, U = Unknownstring-
ThrombolysisOccurence of thrombolysis where Y = True, N = False, U = Unknownstring-
Major_Non_Cerebral_HaemorrhageOccurence of major non-cerebral haemorrhage where Y = True, N = False, U = Unknownstring-
Days_Elapsed_From_Randomization_to_Major_Non_Cerebral_HaemorrhageNumber of days elapsed from randomization to occurrence of major non-cerebral hemorrhageintegerlevel : Ratio
Comment_on_Major_Non_Cerebral_HaemorrhageComment on the occurrence of major non-cerebral hemorrhagestring-
Side_Effect_OthersOccurrence of other side effect where Y = True, N = False, U = Unknownstring-
Days_Elapsed_From_Randomization_to_Side_EffectsNumber of days elapsed from randomization to occurrence of other side effectsintegerlevel : Ratio
Comment_on_Side_EffectComment on the occurrence of other side effectsstring-
Ischaemic_StrokeIschaemic stroke as final diagnosis of initial event where Y = True, N = False, U = Unknownstring-
Haemorrhagic_StrokeHemorrhagic stroke as a final diagnosis of initial event where Y = True, N = False, U = Unknownstring-
Indeterminate_StrokeIndeterminate stroke as final diagnosis of initial event where Y = True, N = False, U = Unknownstring-
Not_A_StrokeNot a stroke as final diagnosis of initial event where Y = True, N = False, U = Unknownstring-
Comment_on_Final_Diagnosis_of_Initial_EventComment on final diagnosis of the initial eventstring-
Recurrent_Ischaemic_StrokeOccurrence of ischaemic recurrent stroke within 14 days where Y = True, N = False, U = Unknownstring-
Days_Elapsed_From_Randomization_to_Recurrent_Ischaemic_StrokeNumber of days elapsed from randomization to occurrence of recurrent ischaemic strokeintegerlevel : Ratio
Recurrent_Haemorrhagic_StrokeOccurrence of haemorrhagic stroke within 14 days where Y = True, N = False, U = Unknownstring-
Days_Elapsed_From_Randomization_to_Recurrent_Haemorrhagic_StrokeNumber of days elapsed from randomization to occurrence of hemorrhagic strokeintegerlevel : Ratio
Unknown_TypeOccurrence of unknown type stroke within 14 days where Y = True, N = False, U = Unknownstring-
Days_Elapsed_From_Randomization_to_Unknown_TypeNumber of days elapsed from randomization to occurrence of an unknown type of strokeintegerlevel : Ratio
Pulmonary_Embolism_Within_14_DaysOccurrence of pulmonary embolism within 14 days where Y = True, N = False, U = Unknownstring-
Days_Elapsed_From_Randomization_to_Pulmonary_EmbolismNumber of days elapsed from randomization to occurrence of pulmonary embolism within 14 daysintegerlevel : Ratio
Discharged_Alive_From_Hospital_Within_14_DaysDischarged alive from hospital within 14 days where Y = True, N = False, U = Unknownstring-
Days_Elapsed_From_Randomization_to_Discharged_Alive_From_HospitalNumber of days elapsed from randomization to discharge alive from the hospital within 14 daysintegerlevel : Ratio
Discharge_DestinationDischarge destination where A = Home, B = Relatives home, C = Residential care, D = Nursing home, E = Other hospital departments and U-Unknownstring-
Dead_on_Discharge_Within_14_DaysThe occurrence of death upon discharge where Y = True, N = False, U = Unknown; This death is not necessarily within 14 days of randomizationstring-
Days_Elapsed_From_Randomization_to_Dead_on_DischargeNumber of days elapsed from randomization to dead on discharge where death is not necessarily within 14 days of randomizationintegerlevel : Ratio
Cause_of_Death_Within_14_DaysCause of death where 1 = Initial stroke, 2 = Recurrent stroke (ischaemic or unknown), 3 = Recurrent stroke (haemorrhagic, 4= Pneumonia, 5 = Coronary heart disease, 6 = Pulmonary embolism, 7 = Other vascular or unknown, 8 = Non-vascular and 0 = unknownstring-
Comment_on_Death_Within_14_DaysComment on death within 14 daysstring-
Dead_at_Six_Month_Follow_UpOccurrence of death at six month follow-up where Y = True, N = False, U = Unknownstring-
Days_Elapsed_From_Randomization_to_Date_of_Last_ContactNumber of days elapsed from randomization to date of the last contactintegerlevel : Ratio
Days_Elapsed_From_Randomization_to_Death_at_Six_Month_Follow_UpNumber of days elapsed from randomization to death at six-month follow-up where death is not necessarily within 6 months of randomizationintegerlevel : Ratio
Cause_of_Death_at_Six_Month_Follow_UpCause of death where 1 = Initial stroke, 2 = Recurrent stroke (ischaemic or unknown), 3 = Recurrent stroke (haemorrhagic, 4= Pneumonia, 5 = Coronary heart disease, 6 = Pulmonary embolism, 7 = Other vascular or unknown, 8 = Non-vascular and 0 = unknownstring-
Comment_on_Death_at_Six_Month_Follow_UpComment on death at six-month follow-upstring-
Fully_Recovered_at_Six_Month_Follow_UpFully recovered at six month follow-up where Y = True, N = False, U = Unknownstring-
Dependent_at_Six_Month_Follow_UpDependent at six month follow-up where Y = True, N = False, U = Unknownstring-
Place_of_Residence_at_Six_Month_Follow_UpPlace of residence at six month follow-up where A = Home, B = Relatives home, C = Residential care, D = Nursing home, E = Other hospital departments and U = Unknownstring-
On_Antiplatelet_Drugs_at_Six_Month_Follow_UpOn antiplatelet drugs at six month follow-up where Y = True, N = False, U = Unknownstring-
On_Anticoagulants_at_Six_Month_Follow_UpOn anticoagulant at six month follow-up where Y = True, N = False, U = Unknownstring-
Days_Elapsed_From_Randomization_to_Date_Discharge_Form_ReceivedNumber of days elapsed from randomization to date discharged form receivedintegerlevel : Ratio
Days_Elapsed_From_Randomization_to_Date_at_Six_Month_Follow_Up_DoneNumber of days elapsed from randomization to date at six-month follow-upintegerlevel : Ratio
Abbreviated_Country_CodeAbbreviated country codestring-
Country_CodeCountry codeintegerlevel : Nominal
Days_Elapsed_From_Randomization_to_Date_Discharge_Form_CompletedNumber of days elapsed from randomization to date discharge form completedintegerlevel : Ratio
Coding_of_ComplianceCoding of compliance where provisional categories for non-compliance are the following:string-
Is_Compliant_for_AspirinCompliance with aspirinboolean-
Is_Compliant_for_HeparinCompliance with heparinboolean-
Is_Death_IndicatorIndicator for deathboolean-
Time_of_Death_in_DaysTime of death or censoring in daysintegerlevel : Ordinal
Predicted_Probability_of_DeathPredicted probability of death or dependence at 6 monthnumberlevel : Ratio
Predicted_Probability_of_Death_at_Six_MonthPredicted probability of death at 6 monthnumberlevel : Ratio
Predicted_Probability_of_Death_at_14_DaysPredicted probability of death at 14 daysnumberlevel : Ratio
Is_Dead_or_Alive_at_14_DaysKnown to be dead or alive at 14 days where 1 = yes and 0 = no; this does not necessarily mean that we know the outcome at 6 monthsboolean-
Is_Death_Indicator_at_14_DaysThe indicator of death at 14 daysboolean-
Six_Month_OutcomeSix month outcome where 1 = dead, 2 = dependent, 3 = not recovered, 4 = recovered, 0 or 9 = missing statusstring-
Is_Initial_Stroke_IndicatorInitial stroke as an indicator variable for the specific cause of deathboolean-
Is_Recurrent_Ischaemic_or_Unknown_Stroke_IndicatorRecurrent ischaemic or unknown stroke as an indicator variable for the specific cause of deathboolean-
Is_Recurrent_Haemorrhagic_Stroke_IndicatorRecurrent hemorrhagic stroke as an indicator variable for the specific cause of deathboolean-
Is_Pneumonia_IndicatorPneumonia as an indicator variable for the specific cause of deathboolean-
Is_Coronary_Heart_Disease_IndicatorCoronary heart disease as an indicator variable for the specific cause of deathboolean-
Is_Pulmonary_Embolism_IndicatorPulmonary embolism as an indicator variable for the specific cause of deathboolean-
Is_Other_Vascular_IndicatorOther vascular or unknown as an indicator variable for the specific cause of deathboolean-
Is_Non_Vascular_IndicatorNon-vascular as an indicator variable for the specific cause of deathboolean-
Is_Haemorrhagic_Stroke_Indicator_Within_14_DaysCerebral bleed/hemorrhagic stroke within 14 days as an indicator variable for the specific cause of death; this is slightly wider definition than DRSH and is used for analysis of cerebral bleedsboolean-
Is_Ischaemic_Stroke_Indicator_Within_14_DaysThe indicator of ischaemic stroke within 14 daysboolean-
Is_Indeterminate_Stroke_Indicator_Within_14_DaysThe indicator of indeterminate stroke within 14 daysboolean-
Is_Any_Stroke_Indicator_Within_14_DaysThe indicator of any stroke within 14 daysboolean-
Is_Haemorrhagic_Transformation_Indicator_Within_14_DaysThe indicator of hemorrhagic transformation within 14 daysboolean-
Is_Pulmonary_Embolism_Indicator_Within_14_DaysThe indicator of pulmonary embolism within 14 daysboolean-
Is_Deep_Vein_Thrombosis_on_DischargeThe indicator of deep vein thrombosis on the discharge formboolean-
Is_Major_Non_Cerebral_Bleed_Indicator_Within_14_DaysThe indicator of major non-cerebral bleed within 14 daysboolean-
Is_Any_Non_Cerebral_Bleed_Indicator_Within_14_DaysThe indicator of any non-cerebral bleed within 14 daysboolean-

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