Others titles
- Human Response to Stressors
- Conditions for Human Stressor
- Events Upon Stressors Testing in Humans
Keywords
- Toxicogenomics
- Gene-Disease Association
- Gene Chemical Pathways
- Exposure Events Database
- Chemical Exposure Results
- Heterogeneous Exposure Information
- Comparative Toxicogenomics Database
- Relationships Between Chemicals and Diseases
- Chemical and Disease Inferences
- Chemical Disease Hypotheses
Exposure Event Associations
This dataset is from the exposure science module added in 2016 to the Comparative Toxicogenomics Database (CTD). The Exposure Events Database collects the effects of chemicals in the environment onto human biology and the measurable events resulting from the exposure to the chemical. The data displayed is a list of research studies with details on the exposure and the outcome of such.
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Description
This dataset is a listing of “exposure studies”that display “heterogeneous exposure information from different articles published by different laboratories in different journals over the decades to become standardized and centralized into a single repository, facilitating connections between unique studies”, including “parameters for a chemical stressor (e.g. ‘air pollutants’), the type of human receptor studied (e.g. ‘study subjects’) and a geographic location (e.g. ‘United States’).”
In the exposure science module the chemical is the exposure stressor, the receptor is the human exposure to the chemical, the exposure event is a measurable biomarker (e.g. amount of a chemical in the blood) or a protein produced or changed due to the exposure, and the exposure-outcome is an alteration in the characteristics of human biology or anatomy (phenotype) or a disease.
The exposure event biomarker or protein is the evidence of the genetic alteration produced by the chemical, and the outcome (e.g. disease) is the product of that alteration. The outcomes are described using Gene Ontology terms.
1. Davis AP, Grondin CJ, Johnson RJ, Sciaky D, King BL, McMorran R, Wiegers J, Wiegers TC, Mattingly CJ. The Comparative Toxicogenomics Database: update 2017. Nucleic Acids Res. 2016 Sep 19;[Epub ahead of print]
About this Dataset
Data Info
Date Created | 2004-01-20 |
---|---|
Last Modified | 2023-04-27 |
Version | 2023-04-27 |
Update Frequency |
Monthly |
Temporal Coverage |
N/A |
Spatial Coverage |
N/A |
Source | John Snow Labs; Comparative Toxicogenomics Database; |
Source License URL | |
Source License Requirements |
Publicly available and free for research application but a citation is required. Permission asked for commercial uses |
Source Citation |
Publicly available and free for research application but a citation is required. Permission asked for commercial uses |
Keywords | Toxicogenomics, Gene-Disease Association, Gene Chemical Pathways, Exposure Events Database, Chemical Exposure Results, Heterogeneous Exposure Information, Comparative Toxicogenomics Database, Relationships Between Chemicals and Diseases, Chemical and Disease Inferences, Chemical Disease Hypotheses |
Other Titles | Human Response to Stressors, Conditions for Human Stressor, Events Upon Stressors Testing in Humans |
Data Fields
Name | Description | Type | Constraints |
---|---|---|---|
Exposure_Stressor_Name | Exposure stressor name. | string | - |
Exposure_Stressor_Id | Identity for exposure stressor. | string | - |
Stressor_Source_Category | The category in which the stressor source lies. | string | - |
Stressor_Source_Details | Detailed description for the stressor source | string | - |
Number_Of_Stressor_Samples | The number of stressor samples. | integer | level : Ratio |
Stressor_Notes | Stressor notes | string | - |
Number_Of_Receptors | Number of individuals on the study or cohort that were exposed to the chemical. | integer | level : Ratio |
Receptor_Description | Type of patients in the cohort and/or their conditions or diseases. | string | - |
Receptor_Notes | Notes on specific characteristics of the group of individuals in the study. | string | - |
Smoking_Status | Smoking status of different individuals in the sampled population. | string | - |
Age | Age of the sampled population. | string | - |
Age_Units_Of_Measurement | string | - | |
Age_Qualifier | The statistical qualifier for the age. | string | - |
Gender | The gender division of the sampled population | string | - |
Race | The racial division of the sampled population | string | - |
Methods | Methods used for detection. | string | - |
Detection_Limit | The detection limit | string | - |
Detection_Limit_Uom | Detection limit unit of measurement. | string | - |
Detection_Frequency | The detection frequency | string | - |
Medium | Biological sample or medium used to test the effects of the chemical. Could be a part of the body, body fluids (i.e. urine, blood), environment elements (i.e. air, water), food, animal species, among others. | string | - |
Exposure_Marker | The exposure marker. | string | - |
Exposure_Marker_Id | The exposure marker identity. | string | - |
Marker_Level | The marker level. | string | - |
Marker_Units_Of_Measurement | string | - | |
Marker_Measurement_Statistic | Measurement statistic in which the marker level is expressed. | string | - |
Assay_Notes | Notes on specific characteristics of the analysis. | string | - |
Study_Location | Country in which the study was performed. | string | - |
State_Or_Province | Relative state or province. | string | - |
City_Town_Region_Area | Relative city, town, region or area. | string | - |
Exposure_Event_Notes | Notes for exposure event | string | - |
Outcome_Relationship | Type of relationship between the chemical and the disease or phenotype (final outcome of the study). This relationship is the result of statistical tests applied in the study; specific statistical tests were not run in all studies. | string | - |
Disease_Name | Name of the disease resulting in the individuals exposed to the stressor. | string | - |
Disease_ID | Unique identifier assigned to the disease by MeSH or OMIM, linked to the source record(s) for the disease. OMIM (Online Medelian Inheritance in Man) is a database of human genes and genetic disorders that displays the type of genetic variation and expression; OMIM uses a six-digit identifier for each gene or genetic disorder. MeSH is a controlled vocabulary of thousands of biomedical terms (including diseases) that serves to standardize the terminology used in published texts that belong to life sciences. Each MeSH term has a unique identifier, which can be from 7 to 8 character length. The MeSH unique identifier was changed to 10-character length after November 2013. | string | - |
Phenotype_Name | Gene ontology of the biological or development characteristics observed in the individuals exposed to the stressor. | string | - |
Phenotype_ID | Phenotype Gene Ontology term ID. Alphanumerical Identification for GO terms. The GO term ID is used to browse the GO terms in the Gene Ontology database. The GO database is a relational database comprised of the GO ontologies as well as the annotations of genes and gene products to terms in those ontologies. The GO database is the source of all data available through the legacy AmiGO 1.8 browser and search engine. | string | - |
Phenotype_Action_Degree_Type | Phenotype action degree type. | string | - |
Anatomy | Anatomical description. | string | - |
Exposure_Outcome_Notes | Relative notes for exposure outcome. | string | - |
Reference | Identification number of the study published in the PubMed database from which the information was obtained. PubMed is a US National Library of Medicine citation database that contains millions of abstracts, references and full-text links of biomedical literature from different trusted sources. | integer | level : Nominal |
Associated_Study_Titles | The associated study titles. | string | - |
Enrollment_Start_Year | Start year for the enrollment. | date | - |
Enrollment_End_Year | End year for the enrollment. | date | - |
Study_Factors | The factors on which the study is based. | string | - |
Data Preview
Exposure Stressor Name | Exposure Stressor Id | Stressor Source Category | Stressor Source Details | Number Of Stressor Samples | Stressor Notes | Number Of Receptors | Receptor Description | Receptor Notes | Smoking Status | Age | Age Units Of Measurement | Age Qualifier | Gender | Race | Methods | Detection Limit | Detection Limit Uom | Detection Frequency | Medium | Exposure Marker | Exposure Marker Id | Marker Level | Marker Units Of Measurement | Marker Measurement Statistic | Assay Notes | Study Location | State Or Province | City Town Region Area | Exposure Event Notes | Outcome Relationship | Disease Name | Disease ID | Phenotype Name | Phenotype ID | Phenotype Action Degree Type | Anatomy | Exposure Outcome Notes | Reference | Associated Study Titles | Enrollment Start Year | Enrollment End Year | Study Factors |
1,1,1-trichloroethane | C024566 | Commercial product|Dietary|Environmental | 63 | Children | Non-smoker | 06-Oct | years | range | Both Males and Females | American Indian 3 | Asian 6 | Black 63 | Hispanic 20 | White 7 | gas chromatography mass spectrometry | 0.024 | nanograms per milliliter | 1.1 | blood | 1,1,1-trichloroethane | C024566 | 0.03 | nanograms per milliliter | 10th percentile | United States | Minnesota | Minneapolis | Feb-01 | 15743726 | The School Health Initiative: Environment, Learning, Disease (SHIELD) | 2001 | 2001 | ||||||||||||||
1,1,1-trichloroethane | C024566 | Commercial product|Dietary|Environmental | 63 | Children | Non-smoker | 06-Oct | years | range | Both Males and Females | American Indian 3 | Asian 6 | Black 63 | Hispanic 20 | White 7 | gas chromatography mass spectrometry | 0.024 | nanograms per milliliter | 1.1 | blood | 1,1,1-trichloroethane | C024566 | 0.03 | nanograms per milliliter | 25th percentile | United States | Minnesota | Minneapolis | Feb-01 | 15743726 | The School Health Initiative: Environment, Learning, Disease (SHIELD) | 2001 | 2001 | ||||||||||||||
1,1,1-trichloroethane | C024566 | Commercial product|Dietary|Environmental | 63 | Children | Non-smoker | 06-Oct | years | range | Both Males and Females | American Indian 3 | Asian 6 | Black 63 | Hispanic 20 | White 7 | gas chromatography mass spectrometry | 0.024 | nanograms per milliliter | 1.1 | blood | 1,1,1-trichloroethane | C024566 | 0.03 | nanograms per milliliter | 50th percentile | United States | Minnesota | Minneapolis | Feb-01 | 15743726 | The School Health Initiative: Environment, Learning, Disease (SHIELD) | 2001 | 2001 | ||||||||||||||
1,1,1-trichloroethane | C024566 | Commercial product|Dietary|Environmental | 63 | Children | Non-smoker | 06-Oct | years | range | Both Males and Females | American Indian 3 | Asian 6 | Black 63 | Hispanic 20 | White 7 | gas chromatography mass spectrometry | 0.024 | nanograms per milliliter | 1.1 | blood | 1,1,1-trichloroethane | C024566 | 0.03 | nanograms per milliliter | 75th percentile | United States | Minnesota | Minneapolis | Feb-01 | 15743726 | The School Health Initiative: Environment, Learning, Disease (SHIELD) | 2001 | 2001 | ||||||||||||||
1,1,1-trichloroethane | C024566 | Commercial product|Dietary|Environmental | 63 | Children | Non-smoker | 06-Oct | years | range | Both Males and Females | American Indian 3 | Asian 6 | Black 63 | Hispanic 20 | White 7 | gas chromatography mass spectrometry | 0.024 | nanograms per milliliter | 1.1 | blood | 1,1,1-trichloroethane | C024566 | 0.04 | nanograms per milliliter | 90th percentile | United States | Minnesota | Minneapolis | Feb-01 | 15743726 | The School Health Initiative: Environment, Learning, Disease (SHIELD) | 2001 | 2001 | ||||||||||||||
1,1,1-trichloroethane | C024566 | Commercial product|Dietary|Environmental | 63 | Children | Non-smoker | 06-Oct | years | range | Both Males and Females | American Indian 3 | Asian 6 | Black 63 | Hispanic 20 | White 7 | gas chromatography mass spectrometry | 0.024 | nanograms per milliliter | 1.1 | blood | 1,1,1-trichloroethane | C024566 | 0.04 | nanograms per milliliter | 95th percentile | United States | Minnesota | Minneapolis | Feb-01 | 15743726 | The School Health Initiative: Environment, Learning, Disease (SHIELD) | 2001 | 2001 | ||||||||||||||
1,1,1-trichloroethane | C024566 | Commercial product|Dietary|Environmental | 63 | Children | Non-smoker | 06-Oct | years | range | Both Males and Females | American Indian 3 | Asian 6 | Black 63 | Hispanic 20 | White 7 | gas chromatography mass spectrometry | 0.024 | nanograms per milliliter | 1.1 | blood | 1,1,1-trichloroethane | C024566 | 0.04 | nanograms per milliliter | 99th percentile | United States | Minnesota | Minneapolis | Feb-01 | 15743726 | The School Health Initiative: Environment, Learning, Disease (SHIELD) | 2001 | 2001 | ||||||||||||||
1,1,1-trichloroethane | C024566 | Commercial product|Dietary|Environmental | 78 | Children | Non-smoker | 06-Oct | years | range | Both Males and Females | American Indian 3 | Asian 6 | Black 63 | Hispanic 20 | White 7 | gas chromatography mass spectrometry | 0.024 | nanograms per milliliter | 2.2 | blood | 1,1,1-trichloroethane | C024566 | 0.03 | nanograms per milliliter | 10th percentile | United States | Minnesota | Minneapolis | May-01 | 15743726 | The School Health Initiative: Environment, Learning, Disease (SHIELD) | 2001 | 2001 | ||||||||||||||
1,1,1-trichloroethane | C024566 | Commercial product|Dietary|Environmental | 78 | Children | Non-smoker | 06-Oct | years | range | Both Males and Females | American Indian 3 | Asian 6 | Black 63 | Hispanic 20 | White 7 | gas chromatography mass spectrometry | 0.024 | nanograms per milliliter | 2.2 | blood | 1,1,1-trichloroethane | C024566 | 0.03 | nanograms per milliliter | 25th percentile | United States | Minnesota | Minneapolis | May-01 | 15743726 | The School Health Initiative: Environment, Learning, Disease (SHIELD) | 2001 | 2001 | ||||||||||||||
1,1,1-trichloroethane | C024566 | Commercial product|Dietary|Environmental | 78 | Children | Non-smoker | 06-Oct | years | range | Both Males and Females | American Indian 3 | Asian 6 | Black 63 | Hispanic 20 | White 7 | gas chromatography mass spectrometry | 0.024 | nanograms per milliliter | 2.2 | blood | 1,1,1-trichloroethane | C024566 | 0.03 | nanograms per milliliter | 50th percentile | United States | Minnesota | Minneapolis | May-01 | 15743726 | The School Health Initiative: Environment, Learning, Disease (SHIELD) | 2001 | 2001 |